NREP
Description
The NREP (neuronal regeneration related protein) is a protein-coding gene located on chromosome 5.
NREP (Neuronal protein 3.1) is a protein encoded by the NREP gene in humans. It is highly expressed in the brain. The gene location and details can be found on the UCSC Genome Browser.
NREP may play a role in neural function, promoting axonal regeneration and influencing cellular differentiation. It is known to increase the motility of gliomas when ectopically expressed. Additionally, NREP can induce the differentiation of fibroblasts into myofibroblasts, leading to ameboid migration. Furthermore, it is involved in the regulation of lipid-droplet biogenesis, particularly in response to retinoic acid. NREP has also been shown to downregulate the expression of TGFB1 and TGFB2, but not TGFB3, potentially playing a role in alveolar generation.
NREP is also known as C5orf13, D4S114, P311, PRO1873, PTZ17, SEZ17.
