NRDE2
Description
The NRDE2 (NRDE-2, necessary for RNA interference, domain containing) is a protein-coding gene located on chromosome 14.
NRDE2 is a nuclear speckle protein that regulates RNA degradation and export from the nucleus by interacting with MTREX. MTREX is a key factor that directs various RNAs for degradation by the nuclear exosome. NRDE2 alters the conformation of MTREX, preventing its interaction with the nuclear exosome and other proteins involved in RNA degradation. This action inhibits the MTREX-mediated recruitment of mRNAs and lncRNAs to the nuclear exosome for degradation. By preventing RNA degradation in the nucleus, NRDE2 promotes the export of these RNAs to the cytoplasm. NRDE2 is also a U5 snRNP-associated RNA splicing factor that is essential for efficient splicing of CEP131 pre-mRNA. It plays a role in centrosome maturation, integrity, and function during mitosis. NRDE2 suppresses intron retention in a subset of pre-mRNAs that contain short, GC-rich introns with weak 5' and 3' splice sites. It also participates in the DNA damage response. NRDE2 interacts directly with MTREX, stabilizing NRDE2. It also interacts with EXOSC10, EFTUD2, and EIF4A3.
NRDE2 is also known as C14orf102.
Associated Diseases
- neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- schizophrenia
- cancer
- brain cancer
- pancreatic ductal adenocarcinoma
