NR2F6
Description
The NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein-coding gene located on chromosome 19.
NR2F6, also known as V-erbA-related protein 2 (EAR-2), is a nuclear receptor protein that is encoded by the NR2F6 gene in humans. It belongs to the nuclear receptor family of intracellular transcription factors and shares similarities with v-erbA, an oncoprotein found in avian erythroblastosis virus. While its exact function is not fully understood, NR2F6 has been shown to act as a coregulator for other nuclear receptors.
NR2F6 primarily functions as a transcriptional repressor. It binds to specific DNA sequences called promoter/enhancer response elements, which contain the imperfect 5'-AGGTCA-3' motif, either directly or in an inverted arrangement, with varying spacing. These motifs are also recognized by other nuclear hormone receptors. NR2F6 plays a role in regulating hormonal responses, inhibiting the expression of genes such as lutropin-choriogonadotropic hormone receptor (LHCGR), renin (REN), and oxytocin-neurophysin (OXT). It also represses the activity of the thyroid hormone receptor gene in a cell-specific manner. This repression involves blocking the binding of the thyroid hormone receptor beta (THRB) to its DNA target sequences (TREs). NR2F6 further inhibits the DNA binding of the NFATC transcription factor, thereby reducing its transcriptional activity. It acts as a repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells, suggesting a potential role in maintaining peripheral immune tolerance and controlling autoimmunity. NR2F6 is also involved in the development of the forebrain circadian clock and is essential for the early development of the locus coeruleus (LC).
NR2F6 is also known as EAR-2, EAR2, ERBAL2.
