NPR1
Description
The NPR1 (natriuretic peptide receptor 1) is a protein-coding gene located on chromosome 1.
NPR1 (Natriuretic Peptide Receptor 1) is a membrane-bound protein that serves as a receptor for both atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). It is primarily found in the kidney, lungs, and adipocytes. Upon binding to ANP or BNP, NPR1 activates its guanylate cyclase activity, leading to the production of cyclic GMP (cGMP). cGMP then acts as a signaling molecule, promoting natriuresis (sodium excretion) and vasodilation. These effects ultimately contribute to the regulation of blood pressure and volume homeostasis.
NPR1 is a receptor for the atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are potent vasoactive hormones involved in regulating blood pressure and volume. When ANP or BNP bind to NPR1, it triggers guanylate cyclase activity, leading to the production of cyclic GMP (cGMP). cGMP then acts as a signaling molecule, promoting vasodilation, natriuresis (sodium excretion), and diuresis (water excretion), ultimately contributing to cardiovascular homeostasis.
NPR1 is also known as ANPRA, ANPa, GUC2A, GUCY2A, NPRA.
