NOTUM
Description
Notum is a highly conserved gene that encodes a protein with a unique catalytic domain responsible for hydrolyzing and inactivating Wnt ligands. This inactivation plays a critical role in modulating the Wnt signaling pathway, a crucial pathway involved in various developmental processes, including cell fate determination, tissue patterning, and organogenesis. Notum acts as a negative regulator of Wnt signaling, ensuring precise spatiotemporal control of Wnt activity during development. This control is vital for normal tissue formation and morphogenesis.
Associated Diseases
Did you know?
Notum was first identified in Drosophila melanogaster and its human homologue was later found to play similar roles in human development.
