NOTO
Description
The NOTO gene, located on chromosome 12, encodes a protein that plays a crucial role in the development and function of the nervous system. This protein, known as NOTCH1, is involved in cell-to-cell signaling, regulating the growth, differentiation, and survival of neurons. Its role extends to the formation of neural circuits and the maintenance of neuronal function throughout life. Mutations in the NOTO gene have been linked to a spectrum of neurological disorders, highlighting its vital role in brain health.
Associated Diseases
- Alagille syndrome
- Cadherins
- Cerebral Cortex Development
- Microcephaly
- Neuroblastoma
- NOTCH signaling pathway
Did you know?
The NOTO gene is involved in the development of the cerebral cortex, the part of the brain responsible for higher cognitive functions such as language, memory, and reasoning.
