NOL9
Description
The NOL9 (nucleolar protein 9) is a protein-coding gene located on chromosome 1.
Nucleolar protein 9 is a protein that in humans is encoded by the NOL9 gene.
NOL9 is a polynucleotide kinase that phosphorylates the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates. It is involved in rRNA processing, specifically in the processing of the 32S precursor into 5.8S and 28S rRNAs, particularly in the generation of the major 5.8S(S) form. NOL9 is required for efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2). It associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for transporting this complex into the nucleolus.
NOL9 is also known as Grc3, NET6.
Associated Diseases
- uncombable hair syndrome
- Griscelli syndrome type 3
- hypotrichosis simplex
- Clouston syndrome
- Waardenburg syndrome, IIa 2F
- schizophrenia
- cancer
