NMUR1
Description
Neuromedin U (NMU) is a neuropeptide that plays a crucial role in regulating various physiological processes, including gastrointestinal function, energy balance, and cardiovascular health. It is synthesized in the hypothalamus and released from nerve endings in the gastrointestinal tract.
NMU primarily binds to the neuromedin U receptor 2 (NMUR2), which is found in the central nervous system, gastrointestinal tract, and cardiovascular system. Activation of NMUR2 triggers a cascade of intracellular signaling events that mediate the effects of NMU.
Associated Diseases
Dysregulated NMU signaling has been implicated in the development of several diseases, including:
- Obesity: NMU deficiency or impaired signaling can lead to increased food intake and weight gain.
- Irritable Bowel Syndrome (IBS): NMU levels are altered in individuals with IBS, contributing to gastrointestinal symptoms such as abdominal pain and diarrhea.
- Cardiovascular Disease: Chronic activation of NMUR2 has been linked to hypertension and cardiac fibrosis.
- Diabetes: NMU has been shown to regulate glucose metabolism, and dysregulation of NMU signaling can impair glucose control.
Did you Know ?
In individuals with obesity, NMU levels are significantly reduced, with a decrease of approximately 50% compared to lean individuals. This finding suggests that impaired NMU signaling may contribute to weight gain and metabolic dysfunction.
