NMT2
Description
The NMT2 (N-myristoyltransferase 2) is a protein-coding gene located on chromosome 10.
NMT2, also known as Glycylpeptide N-tetradecanoyltransferase 2 or N-myristoyltransferase, is an enzyme that attaches a myristoyl group to proteins. This process, called N-terminal myristoylation, is important for the function of many signaling proteins. NMT2 transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. NMT2 is a member of a family of enzymes that includes NMT1. Human NMT2 shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2, respectively.
NMT2 adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. It also mediates N-terminal lysine myristoylation of proteins, such as ARF6, on both 'Gly-2' and 'Lys-3'. Lysine myristoylation is essential for maintaining ARF6 on membranes during the GTPase cycle.
NMT2 is also known as -.
Associated Diseases
- Alzheimer disease
- lysosomal storage disease
- Parkinson disease
- multiple sclerosis
- ovarian cancer
- X-linked retinal dysplasia
- retinitis pigmentosa
- severe early-childhood-onset retinal dystrophy
- reticular dystrophy of the retinal pigment epithelium
- isolated asymptomatic elevation of creatine phosphokinase
- X-linked retinoschisis
- age related macular degeneration 4
