NKD2

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Description

The NKD2 (NKD inhibitor of WNT signaling pathway 2) is a protein-coding gene located on chromosome 5.

NKD2 acts as a cell-autonomous antagonist of the canonical Wnt signaling pathway. It may also activate a second Wnt signaling pathway involved in planar cell polarity. NKD2 is essential for the processing and basolateral targeting of TGFA in polarized epithelial cells.

NKD2 is also known as Naked2.

Associated Diseases

• colorectal cancer
• cancer
• breast cancer