NFYA
Description
The NFYA (nuclear transcription factor Y subunit alpha) is a protein-coding gene located on chromosome 6.
NFYA is a protein that in humans is encoded by the NFYA gene. It is one subunit of the trimeric transcription factor NF-Y, which binds to CCAAT motifs in the promoter regions of various genes. NFYA associates with a dimer of NFYB and NFYC, forming a trimer that binds DNA with high specificity and affinity. The sequence-specific interactions of the complex are primarily mediated by NFYA, suggesting it plays a regulatory role. This gene product is subject to post-transcriptional regulation, potentially through protein degradation or translation control. Further regulation occurs through alternative splicing in the glutamine-rich activation domain, resulting in tissue-specific preferences for the two isoforms. The NF-Y complex acts as a pioneer factor, promoting chromatin accessibility to facilitate other cell type-specific transcription factors. NF-Y is also implicated in transcription start site (TSS) selection in animals, safeguarding the integrity of the nucleosome-depleted region and PIC localization at protein-coding gene promoters. NFYA has been shown to interact with Serum response factor and ZHX1.
NFYA is a subunit of the NF-Y transcription factor complex that binds to the CCAAT box motif in gene promoters. It can act as both an activator and repressor depending on its interacting partners, and positively regulates the transcription of the core clock component BMAL1.
NFYA is also known as CBF-A, CBF-B, HAP2, NF-YA.
Associated Diseases
- Alzheimer disease
- cancer
- 22q11.2 deletion syndrome
- hypoparathyroidism, familial isolated, 2
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- cryohydrocytosis
- thrombocythemia 2
- elliptocytosis 2
