FN1 : fibronectin 1

Description

The FN1 (fibronectin 1) is a protein-coding gene located on chromosome 2.

The FN1 gene produces two main forms of fibronectin-1 protein: soluble plasma fibronectin-1 and insoluble cellular fibronectin-1. Liver cells make soluble plasma fibronectin-1 and release it into the bloodstream, where it primarily contributes to blood clotting and wound healing. This form of fibronectin-1 operates outside of cells, attaching to cell surfaces and binding to other proteins, including other fibronectin-1 molecules. These protein interactions form fibers that aid in tissue repair. Fibronectin-1 binding also helps build the extracellular matrix, a complex network of proteins and other molecules found between cells, which provides structure and strength to tissues that support organs. Various cell types produce insoluble cellular fibronectin-1, which is also released into the extracellular space and helps create fibers and the extracellular matrix. Both types of fibronectin-1 assist individual cells in expanding and migrating to cover larger areas, and influence cell shape and maturation.

Fibronectin-1 binds to cell surfaces and a variety of molecules, including collagen, fibrin, heparin, DNA, and actin. It plays crucial roles in cell adhesion, cell movement, opsonization (marking pathogens for destruction), wound healing, and maintaining cell shape. It also participates in osteoblast compaction through a process called fibronectin fibrillogenesis, which is essential for bone formation. Fibronectin-1 regulates the deposition of type I collagen by osteoblasts. Additionally, it acts as a ligand for the LILRB4 receptor, inhibiting the activation of monocytes by FCGR1A/CD64.

FN1 is also known as CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF, SMDCF.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing