CRKL
Description
The CRKL (CRK like proto-oncogene, adaptor protein) is a protein-coding gene located on chromosome 22.
Crk-like protein is a protein that in humans is encoded by the CRKL gene.
== Function == v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.
== Interactions == CRKL has been shown to interact with:
== See also == Crk
== References ==
== Further reading ==
== External links == Human CRKL genome location and CRKL gene details page in the UCSC Genome Browser.
CRKL plays a role in intracellular signal transduction.
CRKL is also known as -.
