APOL1

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Description

The APOL1 gene plays a crucial role in protecting against trypanosomal infections, particularly African trypanosomiasis. It encodes for apolipoprotein L1, a protein involved in the lysis of trypanosomes, the parasites responsible for this deadly disease. However, specific genetic variants within APOL1 have been linked to an increased risk of kidney diseases, including focal segmental glomerulosclerosis (FSGS) and hypertensive nephropathy. These variants, primarily found in individuals of African descent, disrupt the protein‘s function, leading to the accumulation of harmful substances in the kidneys.

Associated Diseases

• Focal Segmental Glomerulosclerosis (FSGS)
• Hypertensive Nephropathy
• End-Stage Renal Disease (ESRD)
• HIV-Associated Nephropathy

Did you know?

The APOL1 gene exhibits remarkable evolutionary adaptation, with different variants providing protection against specific trypanosome species.