ADAMTS9
ADAMTS9 (A disintegrin and metalloproteinase with thrombospondin motifs 9) is a secreted metalloproteinase enzyme that plays a crucial role in various physiological and pathological processes. It belongs to the ADAMTS family of proteins, characterized by the presence of multiple functional domains, including a prodomain, a metalloproteinase domain, and a disintegrin-like domain. These domains enable ADAMTS9 to interact with a wide range of substrates, including extracellular matrix (ECM) proteins, growth factors, and cell surface receptors.
ADAMTS9 is primarily involved in the proteolysis and remodeling of the ECM, particularly targeting aggrecan, a major component of cartilage. By cleaving aggrecan, ADAMTS9 regulates the structure and integrity of cartilage, influencing its biomechanical properties and susceptibility to degradation.
Dysregulation of ADAMTS9 activity has been implicated in several human diseases, including:
Osteoarthritis (OA): Increased ADAMTS9 expression and activity contribute to the degradation of cartilage in OA, leading to joint pain, stiffness, and reduced mobility. Rheumatoid Arthritis (RA): In RA, ADAMTS9 promotes the inflammatory response by cleaving and activating pro-inflammatory cytokines. Muscle Wasting: ADAMTS9 can degrade muscle-specific ECM proteins, leading to muscle weakness and atrophy observed in cachexia and other muscle-wasting conditions. Cancer: ADAMTS9 is overexpressed in various types of cancer, where it promotes tumor growth, invasion, and metastasis.
Did you Know ?
- ADAMTS9 is the most abundant ADAMTS family member in cartilage, accounting for approximately 95% of the total ADAMTS activity.
