TPRKB
Description
TPRKB, also known as dual specificity tyrosine phosphorylation-regulated kinase B, is a protein kinase that plays a crucial role in various cellular signaling pathways. It is involved in regulating cell growth, survival, and differentiation, and its activity is tightly controlled by a complex network of interactions with other proteins. TPRKB is expressed in a wide range of tissues, including the brain, heart, and immune system, suggesting its broad physiological relevance. Mutations in the TPRKB gene have been linked to several human diseases, highlighting its importance for maintaining cellular homeostasis.
Associated Diseases
- Cancer (e.g., leukemia, lymphoma)
- Neurological disorders (e.g., autism spectrum disorder, schizophrenia)
- Immune system dysfunction
Did you know?
TPRKB is a member of the dual specificity tyrosine phosphorylation-regulated kinase (DYRK) family, which is characterized by its ability to phosphorylate both tyrosine and serine/threonine residues on target proteins.
