TP53RK
Description
TP53RK, also known as p53-related kinase, is a protein kinase that plays a crucial role in cellular processes such as cell cycle regulation, DNA damage response, and apoptosis. TP53RK is a downstream effector of the tumor suppressor p53, and it is activated by various stress signals, including DNA damage, hypoxia, and oxidative stress. Upon activation, TP53RK phosphorylates a variety of substrates, including p53 itself, leading to the induction of cell cycle arrest or apoptosis, thus preventing the proliferation of damaged cells. TP53RK is implicated in the development of various human cancers, and its dysregulation is often associated with tumor progression and metastasis.
Associated Diseases
Did you know?
TP53RK is highly conserved across different species, suggesting its essential role in cellular homeostasis.
