SLC35D1
Description
The SLC35D1 (solute carrier family 35 member D1) is a protein-coding gene located on chromosome 1.
SLC35D1 is an antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar. It transports various UDP-sugars, including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc), and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids, and oligosaccharides. SLC35D1 may couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen, which in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics. It plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development.
SLC35D1 is also known as SHNKND, UGTREL7.
