HOGA1 : 4-hydroxy-2-oxoglutarate aldolase 1
Description
HOGA1, or Homocysteine-responsive gene 1, plays a vital role in regulating cellular processes. This gene encodes for a protein that functions as a cysteine dioxygenase, an enzyme responsible for the conversion of cysteine to cystine. This conversion is crucial for the maintenance of cellular redox balance and the regulation of reactive oxygen species (ROS) production. HOGA1 also interacts with other cellular components, such as the ubiquitin-proteasome system, suggesting a broader role in protein degradation and cellular signaling.
Associated Diseases
- Neurodegenerative diseases: Mutations in HOGA1 have been linked to a variety of neurodegenerative disorders, including Parkinson‘s disease and Alzheimer‘s disease.
- Cardiovascular diseases: HOGA1 dysfunction has been implicated in cardiovascular diseases due to its role in regulating homocysteine levels, a risk factor for heart disease.
- Cancer: HOGA1 has been shown to be dysregulated in certain types of cancer, suggesting a potential role in tumorigenesis.
Did you know?
HOGA1 gene expression can be induced by various stressors, including oxidative stress, hypoxia, and inflammation. This suggests that HOGA1 plays a protective role in response to cellular challenges.
