EMP2
Description
The EMP2 gene, also known as Epithelial Membrane Protein 2, encodes a protein crucial for cell-to-cell adhesion and the establishment of tissue architecture. This transmembrane protein, located on chromosome 16, plays a significant role in various biological processes, including embryonic development, cell differentiation, and tissue repair. EMP2 forms part of the ‘adherens junction‘ complex, a vital structure that connects cells together, ensuring tissue integrity and function. Its intricate role in cell-cell interactions underscores its importance in maintaining the structural and functional integrity of tissues.
Associated Diseases
- Cancer: Mutations in EMP2 have been linked to various cancers, including breast, lung, and colorectal cancers. Abnormal EMP2 expression can contribute to tumor growth and metastasis.
- Cardiac diseases: Dysregulation of EMP2 has been implicated in cardiovascular diseases, potentially impacting heart development and function.
- Developmental disorders: EMP2 mutations are associated with certain developmental abnormalities, affecting the proper formation of organs and tissues.
- Neurological disorders: EMP2‘s role in cell adhesion suggests potential connections to neurological disorders, although further research is needed to confirm these links.
Did you know?
EMP2 expression is particularly high in epithelial tissues, which form the lining of organs and cavities, highlighting its importance in maintaining the barrier function of these tissues.
