EGF

Description

The EGF gene encodes for epidermal growth factor (EGF), a powerful signaling molecule that plays a crucial role in regulating cell growth, proliferation, and differentiation. EGF binds to its receptor, EGFR, initiating a cascade of intracellular signaling pathways that ultimately control various cellular functions. This gene is essential for normal development, wound healing, and tissue repair. Its dysregulation has been implicated in various diseases, particularly cancer.

Associated Diseases

• Cancer (e.g., breast cancer, lung cancer, colorectal cancer)
• Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)
• Cardiovascular diseases
• Skin disorders (e.g., psoriasis, acne)
• Inflammatory diseases

Did you know?

EGF was initially discovered in the 1960s as a factor present in mouse submaxillary glands that promoted the growth of epidermal cells in vitro.