DNAJB13

Description

The DNAJB13 gene provides instructions for making a protein called DNAJB13, a crucial component of the cellular machinery responsible for proper protein folding. This protein acts as a chaperone, assisting other proteins to fold correctly and preventing the formation of harmful protein aggregates. DNAJB13 is particularly active in the endoplasmic reticulum, a cellular organelle vital for protein synthesis and modification. Disruptions in DNAJB13 function can lead to a range of health issues, highlighting its importance in maintaining cellular homeostasis.

Associated Diseases

• Amyotrophic Lateral Sclerosis (ALS)
• Spinocerebellar Ataxia Type 3 (SCA3)
• Parkinson's Disease
• Alzheimer's Disease
• Huntington's Disease
• Other neurodegenerative disorders

Did you know?

DNAJB13 is part of a larger family of chaperone proteins known as J-domain proteins, which play critical roles in a variety of cellular processes.