CLCNKB : chloride voltage-gated channel Kb

Headline: The Vital Role of CLCNKB in Health and Disease

Description:

The CLC family of genes is responsible for producing chloride channels, which facilitate the transport of chloride ions across cell membranes. Among them, the CLCNKB gene holds a crucial role in the kidneys and inner ear.

Associated Diseases:

Mutations in the CLCNKB gene can lead to disorders such as:

• Bartter syndrome type 3
• Gitelman syndrome
• Hypokalemic alkalosis
• Sensorineural hearing loss

These conditions primarily affect kidney function, electrolyte balance, and hearing ability.

Did you Know ?

Bartter syndrome type 3, caused by CLCNKB mutations, affects approximately 1 in 500,000 individuals.