CLCNKB : chloride voltage-gated channel Kb
Headline: The Vital Role of CLCNKB in Health and Disease
Description:
The CLC family of genes is responsible for producing chloride channels, which facilitate the transport of chloride ions across cell membranes. Among them, the CLCNKB gene holds a crucial role in the kidneys and inner ear.
Associated Diseases:
Mutations in the CLCNKB gene can lead to disorders such as:
- Bartter syndrome type 3
- Gitelman syndrome
- Hypokalemic alkalosis
- Sensorineural hearing loss
These conditions primarily affect kidney function, electrolyte balance, and hearing ability.
Did you Know ?
Bartter syndrome type 3, caused by CLCNKB mutations, affects approximately 1 in 500,000 individuals.
