NENF
Description
The NENF (neudesin neurotrophic factor) is a protein-coding gene located on chromosome 1.
NENF acts as a neurotrophic factor in postnatal mature neurons, promoting neuronal survival. It also plays a role in cell proliferation and neurogenesis in undifferentiated neural progenitor cells during embryonic development, while inhibiting astrocyte differentiation. Its neurotrophic activity is mediated through the MAPK1/ERK2, MAPK3/ERK1, and AKT1/AKT signaling pathways. Binding to heme enhances its neurotrophic activity. NENF also functions as an anorexigenic neurotrophic factor contributing to energy balance.
NENF is also known as CIR2, SCIRP10, SPUF.
