NDUFB6
Description
The NDUFB6 (NADH:ubiquinone oxidoreductase subunit B6) is a protein-coding gene located on chromosome 9.
NDUFB6, also known as Complex I-B17, is a protein encoded by the NDUFB6 gene in humans. It serves as an accessory subunit within the NADH dehydrogenase (ubiquinone) complex, located in the mitochondrial inner membrane. This complex, also referred to as Complex I, is the largest among the five complexes involved in the electron transport chain. The NDUFB6 gene resides on chromosome 9, specifically on the p arm at position 21.1, spanning 19,659 base pairs. The protein itself weighs 15.5 kDa and comprises 128 amino acids. NDUFB6's structure resembles an L-shape with a hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm. This structure is crucial for its function, with the hydrophobic domain acting as an anchor for the complex at the inner mitochondrial membrane. Although NDUFB6 is not directly involved in catalysis, it plays a vital role in facilitating electron transfer activity.
NDUFB6 is also known as B17, CI.
Associated Diseases
- type 2 diabetes mellitus
- type 1 diabetes mellitus
- schizophrenia
- breast cancer
- bipolar disorder
- urinary bladder carcinoma
