NDUFA3
Description
The NDUFA3 (NADH:ubiquinone oxidoreductase subunit A3) is a protein-coding gene located on chromosome 19.
NDUFA3, a human gene, encodes a protein called NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3. This protein is a component of NADH dehydrogenase (ubiquinone), located in the inner membrane of mitochondria. It is the largest of the five complexes in the electron transport chain, responsible for transferring electrons from NADH to ubiquinone. The gene is located on chromosome 19, spanning 4,123 base pairs. The protein, weighing 9.3 kDa, consists of 84 amino acids. NDUFA3 is one of 31 hydrophobic subunits that contribute to the transmembrane region of Complex I, forming an L-shaped structure with a hydrophobic transmembrane domain and a hydrophilic domain for the peripheral arm containing the redox centers and NADH binding site. The hydrophobic domain acts as an anchor for the Complex I at the inner mitochondrial membrane. Although NDUFA3 is a subunit of Complex I, it is considered an accessory subunit that is not involved in the catalytic transfer of electrons.
NDUFA3 is also known as B9, CI-B9.
Associated Diseases
- type 2 diabetes mellitus
- type 1 diabetes mellitus
- schizophrenia
- breast cancer
- bipolar disorder
- urinary bladder carcinoma
- prostate cancer
