NDC80
Description
The NDC80 (NDC80 kinetochore complex component) is a protein-coding gene located on chromosome 18.
NDC80 is a protein encoded by the NDC80 gene in humans. It is a component of the outer kinetochore, forming a heterotetramer with NUF2, SPC25, and SPC24 proteins. This complex contains microtubule-binding domains and is involved in spindle checkpoint signaling, ensuring correct chromosome segregation during cell division.
NDC80 is a crucial component of the NDC80 complex, a vital structure associated with kinetochores. This complex plays a key role in ensuring proper chromosome segregation during cell division and maintaining spindle checkpoint activity. It is essential for the integrity of kinetochores and the establishment of stable microtubule binding sites at the outer kinetochore plate. The NDC80 complex enhances the affinity of the SKA1 complex for microtubules and may enable the NDC80 complex to track depolymerizing microtubules. NDC80 is involved in chromosome congression and is essential for the end-on attachment of kinetochores to spindle microtubules.
NDC80 is also known as HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80.
Associated Diseases
- nonpapillary renal cell carcinoma
- cancer
- glioblastoma
- osteopathia striata with cranial sclerosis
- cervical squamous intraepithelial neoplasia
