NCOR2
Description
The NCOR2 (nuclear receptor corepressor 2) is a protein-coding gene located on chromosome 12.
The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression. NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).
== Function == NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains. NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of histone deacetylases to the DNA promoters bound by its interacting transcription factors.
== Family == It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 1.
== Discovery == SMRT was initially cloned and characterized in the laboratory of Dr. Ronald M. Evans at the Salk Institute for Biological Studies.
NCOR2 is a transcriptional corepressor that negatively regulates the activity of certain nuclear receptors. This is achieved by promoting chromatin condensation, which hinders access for the transcription machinery. NCOR2 exists in different isoforms (1 and 4) with distinct affinities for specific nuclear receptors. NCOR2 plays a role in BCL6-dependent regulation of germinal center reactions, primarily influencing the proliferation and survival of GC B cells. It is recruited by ZBTB7A to androgen response elements (ARE) on target genes, leading to the suppression of androgen receptor signaling and androgen-induced cell proliferation.
NCOR2 is also known as CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1.
