NCOR1
Description
The NCOR1 (nuclear receptor corepressor 1) is a protein-coding gene located on chromosome 17.
NCOR1 is a protein encoded by the NCOR1 gene in humans. It acts as a corepressor in gene transcription, interacting with nuclear receptors and recruiting histone deacetylases to DNA promoter regions. This leads to the downregulation of gene expression. NCOR1 belongs to the family of nuclear receptor corepressors, with NCOR2 being the other human member of the family. Interestingly, loss of function in NCOR1 has been shown to significantly enhance muscle strength and power in mice.
NCOR1 mediates transcriptional repression by certain nuclear receptors, contributing to the formation of repressive chromatin structures that hinder the access of basal transcription factors. It participates in the transcriptional repression activity produced by BCL6. ZBTB7A recruits NCOR1 to androgen response elements (ARE) on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. NCOR1 also mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and genes involved in lipid metabolism in the liver.
NCOR1 is also known as N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR.
Associated Diseases
- urinary bladder carcinoma
- skin squamous cell carcinoma
- carcinoma of liver and intrahepatic biliary tract
- skin basal cell carcinoma
