MYOZ2
Description
The MYOZ2 (myozenin 2) is a protein-coding gene located on chromosome 4.
Myozenin-2, also referred to as Calsarcin-1, is a protein encoded by the MYOZ2 gene in humans. The Calsarcin-1 isoform, expressed in cardiac and slow-twitch skeletal muscle, functions to bind calcineurin to alpha-actinin at Z-discs, inhibiting pathological cardiac hypertrophy. This differs from the fast-skeletal muscle isoform, calsarcin-2. Calsarcin-1 is a 29.9 kDa protein consisting of 264 amino acids, exhibiting only 31% homology with calsarcin-2. It binds to alpha-actinin, gamma-filamin, telethonin, ZASP/Cypher, and calcineurin. The binding region to alpha-actinin is localized to amino acids 153-200, while that to calcineurin is amino acids 217-240. Mice lacking the MYOZ2 gene show heightened sensitivity to calcineurin signaling in both muscle types, with increased slow-twitch muscle fibers in slow-skeletal muscle.
MYOZ2 is also known as C4orf5, CMH16, CS-1, FATZ-2.
