MYOF
Description
The MYOF (myoferlin) is a protein-coding gene located on chromosome 10.
Myoferlin is a protein encoded by the MYOF gene in humans. It is structurally similar to dysferlin, another protein associated with the plasma membrane, and is a type II membrane protein belonging to the ferlin family. Myoferlin associates with both plasma and nuclear membranes. It contains C2 domains, which play a role in calcium-mediated membrane fusion events, suggesting involvement in membrane regeneration and repair. It also contains a FerA domain, which interacts with the membrane, contributing to myoferlin's membrane interaction mechanism. Myoferlin is overexpressed in various cancers, particularly pancreas and triple-negative breast cancer. Overexpression is linked to proliferation, migration, and invasion of cancer cells, and silencing myoferlin's gene in triple-negative breast cancer significantly reduces tumor growth and metastatic progression. Two transcript variants encoding different isoforms have been found for this gene.
MYOF is also known as FER1L3, HAE7.
