MYF6
Description
The MYF6 (myogenic factor 6) is a protein-coding gene located on chromosome 12.
Myogenic factor 6 (MYF6), also known as Mrf4 or herculin, is a protein encoded by the MYF6 gene in humans. It's a myogenic regulatory factor (MRF) involved in myogenesis (muscle formation). MYF6 is a basic helix-loop-helix (bHLH) transcription factor, like other MRFs. While its exact role in myogenesis is not fully understood, studies in mice show that MYF6 can initiate myogenesis even without other MRFs (Myf5 and MyoD). The bHLH domain is essential for MYF6's role in myogenesis regulation. MYF6 is specifically expressed in skeletal muscle and at higher levels in adult muscle compared to other MRF family genes. In mice, MYF6 exhibits a unique two-phase expression pattern compared to other MRFs.
MYF6 is also known as CNM3, MRF4, bHLHc4, myf-6.
