MXRA8
Description
The MXRA8 (matrix remodeling associated 8) is a protein-coding gene located on chromosome 1.
MXRA8 (Matrix Remodeling Associated 8) is a protein encoded by the MXRA8 gene in humans. The MXRA8 protein serves as a receptor for several arthritogenic alphaviruses, including chikungunya, Ross River, Mayaro, and O'nyong nyong viruses.
MXRA8 is a transmembrane protein that modulates various signaling pathways, likely by binding to integrin ITGAV:ITGB3. It facilitates heterophilic cell-cell interactions in vitro. MXRA8 inhibits osteoclastogenesis, potentially by attenuating signaling via integrin ITGB3 and MAP kinase p38. It contributes to cartilage formation by promoting chondrocyte proliferation and maturation, stimulating primary cilia formation, and enhancing hedgehog signaling pathway gene expression. In angiogenesis, MXRA8 suppresses endothelial cell migration and promotes apoptosis. It inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells and also inhibits VTN-mediated integrin ITGAV:ITGB3 signaling and PTK2/FAK activation. MXRA8 may play a role in blood-brain barrier maturation and maintenance.
MXRA8 is also known as ASP3.
Associated Diseases
- breast cancer
- Griscelli syndrome type 3
- cancer
- uncombable hair syndrome
- oculocutaneous albinism type 3
- piebald trait-neurologic defects syndrome
