MXI1
Description
The MXI1 (MAX interactor 1, dimerization protein) is a protein-coding gene located on chromosome 10.
MXI1, encoded by the MXI1 gene, is a protein that plays a role in regulating the expression of the c-myc gene. This gene produces an oncogenic transcription factor, meaning it can contribute to cancer development. MXI1 acts as a transcriptional repressor, preventing the c-myc gene from being overactive. It does this by binding to MAX, a protein required for MYC function, effectively blocking MYC's activity. This makes MXI1 a potential tumor suppressor. Mutations in MXI1 are frequently seen in patients with prostate tumors, indicating its importance in controlling cell growth. There are different versions of MXI1 produced through alternative splicing, leading to diverse isoforms.
MXI1 functions as a transcriptional repressor by binding to MAX, a protein essential for MYC's function. This binding forms a complex that recognizes the DNA sequence 5'-CAC[GA]TG-3'. By competing with MYC for MAX, MXI1 inhibits the transcriptional activity of MYC.
MXI1 is also known as MAD2, MXD2, MXI, bHLHc11.
