MUC13
Description
The MUC13 (mucin 13, cell surface associated) is a protein-coding gene located on chromosome 3.
Mucins are large, heavily glycosylated proteins produced by epithelial tissues in most animals. They form gels, contributing to various functions like lubrication, cell signaling, and barrier formation. Some mucins play a role in controlling mineralization, while others bind to pathogens as part of the immune system. Overexpression of certain mucins, particularly MUC1, is linked to cancer. Most mucins are secreted, forming mucus or saliva. Human mucins are categorized into secreted and membrane-bound (transmembrane) groups. MUC13 is a membrane-bound mucin, along with MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC15, MUC16, MUC17, MUC21, and MUC22. The major secreted airway mucins are MUC5AC and MUC5B, while MUC2 is primarily secreted in the intestine but also in the airway.
MUC13 is also known as DRCC1, MUC-13.
