MTUS1
Description
The MTUS1 (microtubule associated scaffold protein 1) is a protein-coding gene located on chromosome 8.
MTUS1, also known as Mitochondrial tumor suppressor 1 (MTSG1) or Microtubule-Associated Scaffold Protein 1 (MTUS1), is a protein that acts as a tumor suppressor in humans. Its gene, MTUS1, can be found in various human cancers, including colon, ovarian, head-and-neck, pancreas, breast, bladder, gastric, and lung cancers. MTUS1 comes in five different forms (ATIP1, ATIP2, ATIP3a, ATIP3b, and ATIP4) due to alternative splicing, with ATIP3 being the most common. This protein has a region at the end that interacts with the Angiotensin II receptor type 2 (AT2) and a long coiled-coil region that lets it bind to itself. Some forms of MTUS1 are found inside mitochondria, where they act as tumor suppressors and are involved in AT2 signaling. Other forms may be found in the nucleus or cell membrane, but it's not clear if they also take part in AT2 signaling. MTUS1 interacts with Angiotensin II receptor type 2.
MTUS1 works with AGTR2 to block ERK2 activation and cell growth. It might be needed for AGTR2 to be on the cell surface. Along with PTPN6, it increases UBE2V2 production when angiotensin-II is present. The first form of MTUS1 slows down breast cancer cell growth, makes mitosis take longer by stretching out metaphase, and shrinks tumors.
MTUS1 is also known as ATBP, ATIP, ATIP3, ICIS, MP44, MTSG1.
Associated Diseases
- toxemia of pregnancy
- urinary bladder carcinoma
- cancer
- systemic lupus erythematosus
- autoinflammatory syndrome with immunodeficiency
- hemoglobin D disease
- autoimmune lymphoproliferative syndrome type 4
- DDX41-related hematologic malignancy predisposition syndrome
- autoimmune lymphoproliferative syndrome type 2A
- erythroleukemia, familial, susceptibility to
- immunodeficiency 69
- lymphoproliferative syndrome 1
