MTL5
Metallothionein 5 (MTL5)
Description:
Metallothionein 5 (MTL5) is a protein found in humans that plays a crucial role in cellular metabolism and protection. It belongs to a family of small, cysteine-rich proteins known as metallothioneins, which are known for their ability to bind to various heavy metals. MTL5 is primarily expressed in the brain and other neural tissues, reflecting its importance in neuronal function.
Associated Diseases:
MTL5 has been implicated in several neurological disorders, including:
- Alzheimer's disease: Studies have shown decreased levels of MTL5 expression in the brains of Alzheimer's patients, suggesting its role in protecting against neuronal damage and inflammation.
- Parkinson's disease: MTL5 has been found to interact with proteins associated with Parkinson's disease, and its deficiency may contribute to neuron loss and motor impairments.
- Multiple sclerosis: MTL5 has been found to be downregulated in multiple sclerosis patients, indicating its involvement in the inflammatory and neurodegenerative processes of the disease.
Did you Know ?
Studies have found that individuals with a genetic variation in the MTL5 gene may have an increased risk of developing Alzheimer's disease. Specifically, a mutation in a single nucleotide of the MTL5 gene has been associated with an approximately 25% higher risk of Alzheimer's disease.
