MTF2
Description
The MTF2 (metal response element binding transcription factor 2) is a protein-coding gene located on chromosome 1.
MTF2 is a Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. MTF2 regulates transcriptional networks during embryonic stem cell self-renewal and differentiation. It promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. MTF2 is required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions, MTF2 may act as an inhibitor of PRC2 activity, activating the CDKN2A gene and promoting cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. MTF2 binds to the metal-regulating-element (MRE) of MT1A gene promoter.
MTF2 is also known as M96, PCL2, TDRD19A, dJ976O13.2.
Associated Diseases
- endometrial cancer
- autosomal recessive spondylocostal dysostosis
- autosomal dominant brachyolmia
- autosomal dominant spondylocostal dysostosis
- spondylometaphyseal dysplasia, A4 type
- thoracolaryngopelvic dysplasia
- spondyloepiphyseal dysplasia tarda, Kohn type
