MSI2
Description
The MSI2 (musashi RNA binding protein 2) is a protein-coding gene located on chromosome 17.
Musashi-2, also known as Musashi RNA binding protein 2, is a protein encoded by the MSI2 gene in humans. Like its homologue Musashi-1 (MSI1), it is an RNA-binding protein involved in stemness. There are two homologue genes found in mammals, called musashi1 (MSI1) and musashi-2 (MSI2). Musashi-2 is an RNA-binding protein expressed in neuronal progenitor cells, including stem cells, and both normal and leukemic blood cells. Musashi-2 also appears to be expressed in stem cells and in a wide variety of tissues, including the bulge region of the hair follicle, immature pancreatic β-cells and neural progenitor cells. Among neural progenitor cells, MSI2 is expressed in early stages of development, in the ventricular and subventricular zone, in cells of the astrocyte lineage. It was there that it was first discovered. Within the hematopoietic system, MSI2 is highly expressed in the most primitive progenitors, in stem cell compartments, and its overexpression has been found in myeloid leukemia cell lines. In neural cell lines, MSI2 protein, as well as its homologue MSI1, is exclusively located in the cytoplasm. In humans, the MSI2 gene is located in chromosome 17q23.2.
MSI2 is also known as MSI2H.
