MSI1
Description
The MSI1 (musashi RNA binding protein 1) is a protein-coding gene located on chromosome 12.
MSI1, also known as Musashi-1, is a protein encoded by the MSI1 gene in humans. It contains two conserved tandem RNA recognition motifs and functions as an RNA binding protein involved in post-transcriptional gene editing. MSI1 is a stem cell marker that controls the balance between self-renewal and terminal differentiation. Overexpression of MSI1 is associated with the grade of malignancy and proliferative activity in gliomas and melanomas. Increased expression of MSI1 protein is observed in endometriosis and endometrial carcinoma. Inhibition of MSI1 expression in endometrial carcinoma cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway. MSI1 is highly expressed in neural progenitor cells and is required for normal development of the brain. A mutation in the MSI1 gene is responsible for autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome, which may explain why these cells are highly susceptible to Zika virus infection.
MSI1 is also known as -.
Associated Diseases
- substance abuse
- cancer
- Mobius syndrome
- glioblastoma
- retinitis pigmentosa
- skin basal cell carcinoma
- X-linked retinal dysplasia
