MRI1
Description
The MRI1 (methylthioribose-1-phosphate isomerase 1) is a protein-coding gene located on chromosome 19.
MRI1 catalyzes the conversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). This enzyme also plays a role in cell invasion, promoting FAK tyrosine phosphorylation and stress fiber turnover when RhoA is constitutively activated. These actions are independent of its catalytic activity.
MRI1 is also known as M1Pi, MRDI, MTNA, Ypr118w.
Associated Diseases
- infantile epilepsy syndrome
- glycoprotein storage disease
- hemoglobin H disease
- hemoglobin C-beta-thalassemia syndrome
- combined immunodeficiency due to OX40 deficiency
- dominant beta-thalassemia
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- erythroleukemia, familial, susceptibility to
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
- hereditary neutrophilia
