MOV10L1
Description
The MOV10L1 (Mov10 like RNA helicase 1) is a protein-coding gene located on chromosome 22.
MOV10L1 is an ATP-dependent RNA helicase crucial for spermatogenesis. It plays a vital role in repressing transposable elements (TEs) and preventing their mobilization, which is essential for germline integrity. This repression is achieved through the piRNA metabolic pathway, which involves the formation of complexes composed of piRNAs and Piwi proteins. MOV10L1 is involved in the primary piRNA metabolic process, specifically binding to piRNA precursors and facilitating the generation of intermediate piRNA processing fragments. These fragments are then loaded onto Piwi proteins. MOV10L1 utilizes its ATP-dependent RNA helicase activity to unwind and funnel single-stranded piRNA precursor transcripts towards the endonuclease responsible for the first cleavage step in piRNA processing. This process produces the intermediate fragments that are eventually loaded onto Piwi proteins.
MOV10L1 is also known as CHAMP, DJ402G11.8, SPGF73.
Associated Diseases
- Male infertility with azoospermia or oligozoospermia due to single gene mutation
- Spermatogenic failure 73
