MLNR
Description
The MLNR (motilin receptor) is a protein-coding gene located on chromosome 13.
The Motilin receptor, formerly known as GPCR38, is a G protein-coupled receptor that binds motilin. It was discovered in 1999 by Merck Laboratories. The receptor's primary structure comprises 412 amino acids, forming a tertiary structure resembling a golf club. The C-terminal protects against enzymatic degradation, while the N-terminal is crucial for binding motilin. Its primary function is to contract gastric smooth muscle during phase III of the migrating motor complex (MMC). In this phase, N-type motilin receptors in the distal antral pump of the stomach are activated, leading to gastric smooth muscle contraction, food sieving into the small intestine, and stomach preparation for the next meal. Motilin, an intestinal peptide produced by enteroendocrine cells in the proximal small intestine, stimulates gastric smooth muscle contraction through the motilin receptor. It is secreted cyclically.
MLNR is also known as GPR38, MTLR1.
Associated Diseases
- ovarian cancer
- biliary tract cancer
- type 1 diabetes mellitus
- malignant tumor of extrahepatic bile duct
- multiple sclerosis
