MISP
Description
The MISP (mitotic spindle positioning) is a protein-coding gene located on chromosome 19.
MISP, short for Malware Information Sharing Platform, is an open-source platform that facilitates the sharing of threat intelligence. Developed to address the inefficiencies of sharing Indicators of Compromise (IOCs) through emails or PDFs, MISP enables automated processing and analysis of security information. The project originated in 2011 as a personal project by Christophe Vandeplas, who sought a more efficient way to share security data. The platform quickly gained traction and is now widely used by various organizations, including the Belgian Defence and NATO.
MISP plays a crucial role in cell division, specifically in ensuring proper positioning of the mitotic spindle. It influences the distribution of dynactin, a protein complex, at the cell cortex, contributing to the stability of microtubule attachments and proper spindle alignment. It may also be involved in connecting microtubules to the actin cytoskeleton and focal adhesions, suggesting roles in cell migration and centrosome positioning. Additionally, MISP might be essential for maintaining the correct structure of the Golgi apparatus.
MISP is also known as C19orf21, MISP1.
Associated Diseases
- inflammatory bowel disease 30
- inflammatory bowel disease 1
- infantile convulsions and choreoathetosis
- juvenile polyposis syndrome
- congenital enterocyte heparan sulfate deficiency
- gastric adenocarcinoma and proximal polyposis of the stomach
- NK-cell enteropathy
- palmoplantar keratoderma-esophageal carcinoma syndrome
- familial visceral myopathy
- cancer
- eosinophilic gastroenteritis
- immunodeficiency due to MASP-2 deficiency
