MIR5095
mir5095: A microRNA with Diverse Roles in Health and Disease
Description:
mir5095 is a small non-coding RNA molecule that plays a crucial role in gene regulation. It is abundantly expressed in various tissues, including the heart, brain, and immune system. Mir5095 exerts its effects by targeting and suppressing the expression of specific messenger RNAs (mRNAs), thereby influencing cellular processes such as proliferation, differentiation, and apoptosis.
Associated Diseases:
Aberrant expression of mir5095 has been implicated in a wide range of human diseases, including:
- Cardiovascular diseases: Mir5095 promotes angiogenesis, a key process in heart development and repair. Dysregulation of mir5095 has been linked to coronary artery disease, myocardial infarction, and heart failure.
- Neurodegenerative disorders: Mir5095 modulates neuronal survival and synaptic plasticity. Its deficiency or overexpression has been associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
- Immune disorders: Mir5095 regulates immune cell function and inflammation. Alterations in its expression have been observed in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease.
- Cancer: Mir5095 can act as either a tumor suppressor or an oncogene, depending on the cellular context. Dysregulated mir5095 expression has been reported in various cancers, including breast cancer, lung cancer, and colorectal cancer.
Did you Know ?
Approximately 30% of human genes are estimated to be regulated by miRNAs, including mir5095. This highlights the significant impact of miRNAs on gene expression and cellular function.
