MIOS
Description
The MIOS (meiosis regulator for oocyte development) is a protein-coding gene located on chromosome 7.
MIOS or Meter Inter Operability Solution is a specification for interoperability of electric meters for remote meter reading applications in India proposed by IEEMA in 2008. and is developed and maintained by Metering India which is a group of Meter Manufacturers.
== See also == Bureau of Indian Standards Indian Electrical and Electronics Manufacturers Association(IEEMA) IEC 62056 is a set of standards for Electricity metering data exchange by International Electrotechnical Commission.
MIOS, also known as Missing oocyte meiosis regulator homolog, is a component of the GATOR2 complex. It functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 by inhibiting the GATOR1 subcomplex. GATOR2 likely acts as an E3 ubiquitin-protein ligase towards GATOR1. In the presence of abundant amino acids, GATOR2 ubiquitinates the NPRL2 core component of GATOR1, leading to its inactivation. Conversely, in the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, MIOS is essential for preventing autoubiquitination of WDR24, the catalytic subunit. The GATOR2 complex is crucial for brain myelination. It forms a subcomplex composed of MIOS, SEC13, SEH1L, WDR24, and WDR59. The GATOR2 complex interacts with CASTOR1 and CASTOR2, an interaction negatively regulated by arginine. CASTOR1 and CASTOR2 relay leucine availability through direct interaction with MIOS. Additionally, GATOR2 interacts with SESN1, SESN2, and SESN3, an interaction negatively regulated by amino acids. MIOS directly interacts with SAR1A and SAR1B, a connection disrupted by leucine. This interaction mediates the association of SAR1A or SAR1B with the GATOR2 complex to negatively regulate TORC1 signaling upon leucine deprivation.
MIOS is also known as MIO, Sea4, Yulink.
