MIEF1
Description
The MIEF1 (mitochondrial elongation factor 1) is a protein-coding gene located on chromosome 22.
MIEF1 is a mitochondrial outer membrane protein that regulates mitochondrial fission. It promotes the recruitment of dynamin-related protein 1 (DNM1L), a fission mediator, to the mitochondrial surface independently of FIS1 and MFF, other mitochondrial fission proteins. MIEF1 also regulates DNM1L GTPase activity and oligomerization. It binds ADP and GDP, but does not bind other nucleotides like CDP, UDP, ATP, AMP, or GTP. In the absence of bound ADP, MIEF1 inhibits DNM1L GTPase activity. However, when ADP is bound, it stimulates DNM1L GTPase activity and causes DNM1L to assemble into long, oligomeric tubules with a spiral pattern, in contrast to the ring-like oligomers observed without bound ADP. MIEF1's recruitment of DNM1L does not require ADP.
MIEF1 is also known as AltMIEF1, D3A, HSU79252, L0R8F8, MID51, MIEF1-MP, OPA14, SMCR7L, dJ1104E15.3.
