MICALL2
Description
The MICALL2 (MICAL like 2) is a protein-coding gene located on chromosome 7.
MICALL2, also known as Junctional Rab13-binding protein, is a key regulator of cell adhesion and cytoskeletal organization. It acts as an effector of small Rab GTPases, controlling the trafficking of cell adhesion molecules, such as occludins, claudins, and E-cadherin, to the plasma membrane. This regulation is crucial for the formation of tight junctions and adherens junctions, which are essential for cell-cell interactions and tissue integrity. MICALL2 also influences actin cytoskeletal reorganization, both directly by interacting with F-actin and indirectly through interactions with actinins and filamins. Its involvement in these processes likely contributes to epithelial cell differentiation, cell spreading, and neurite outgrowth.
MICALL2 is also known as JRAB, MICAL-L2.
