MICAL3
Description
The MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3) is a protein-coding gene located on chromosome 22.
MICAL3, also known as Microtubule-associated monoxygenase, calponin and LIM domain containing 3, is a human gene. MICAL3 works in conjunction with Rab6 and Rab8 proteins in the docking and fusion of vesicles involved in exocytosis.
MICAL3 is an enzyme that breaks down F-actin, a protein that makes up the cytoskeleton. It does this by adding oxygen to specific methionine residues on actin, which changes the shape of the actin and causes it to fall apart. MICAL3 can also act as a NADPH oxidase, which means it can produce hydrogen peroxide. MICAL3 is involved in the process of vesicle trafficking, which is the movement of small sacs of molecules within cells. MICAL3 helps to attach vesicles to other parts of the cell and to fuse them with the cell membrane. This process is important for releasing molecules from the cell. MICAL3 is also required for cytokinesis, which is the process by which a cell divides into two daughter cells. MICAL3 helps to stabilize the bridge that forms between the two daughter cells, which allows them to separate properly.
MICAL3 is also known as MICAL-3.
