METRN
Description
The METRN (meteorin, glial cell differentiation regulator) is a protein-coding gene located on chromosome 16.
The METRN gene encodes the protein Meteorin, which plays a significant role in glial cell differentiation and axonal network formation during neurogenesis. Meteorin promotes glial cell differentiation, specifically the development of astrocytes and the transformation of cerebellar astrocytes into radial glia. It also contributes to axonal outgrowth by activating satellite glial cells, which in turn stimulate axonal extension in small and intermediate neurons of sensory ganglia. Meteorin's neurotrophic properties make it a potential therapeutic target for neuropathic pain. The human variant of Meteorin is currently under development by Hoba Therapeutics for the treatment of neuropathic pain.
METRN plays a crucial role in both glial cell differentiation and the formation of axonal networks during neurogenesis. It promotes astrocyte differentiation and converts cerebellar astrocytes into radial glia. Additionally, METRN stimulates axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.
METRN is also known as C16orf23, c380A1.2.
Associated Diseases
- glioblastoma
- hereditary neutrophilia
- hemoglobin H disease
- immunodeficiency 75
- dominant beta-thalassemia
- hemoglobin C-beta-thalassemia syndrome
- glycoprotein storage disease
- hemolytic anemia due to diphosphoglycerate mutase deficiency
- erythroleukemia, familial, susceptibility to
- familial isolated congenital asplenia
- combined immunodeficiency due to OX40 deficiency
